CROSSING THE WAY OF PRECISION MEDICINE APPROACH IN PERSONALIZED MEDICINE RESEARCH CENTER: A SYSTEMATIC REVIEW

Background: Precision medicine is a new approach in the field of medical sciences that utilizes the genetic characteristics of each patient along with clinical information to guide decisions related to diagnosis and early treatment of diseases. The Personalized Medicine Research Center, as the only center approved by the Ministry of Health, is working on precision medicine context and producing the related knowledge. Methods: In this systematic review, studies that are conducted at the personalized medicine research center with a precision medicine theme based on specific eligibility criteria and a designed search strategy in three databases PubMed, Scopus, and Web of Science (Wos) from December 2016 to December 2019 were retrieved. Results: Finally, 18 studies focusing on different approaches of precision medicine in prediction, prevention through “omics” including genomics, transcriptomics, and proteomics were selected for further evaluation. Finally, 18 studies focusing on precision medicine in non-communicable diseases (diabetes) and cancer (prostate and thyroid) were selected for further studies. Conclusion: Since one of the important goals of precision medicine is prediction and prevention, the identified genetic changes can be used for early diagnosis in high-risk individuals. Actually, the initiative studies are needed to meet the goal of precision medicine.